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Presenter Perspectives: Stromal Engagement in Adipose—Adipogenesis vs. Fibrosis


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1 minute

Stromal Engagement in Adipose—Adipogenesis vs. Fibrosis

Monday, June 28, at 9:30 a.m. ET

Q&A with Rana K. Gupta, PhD

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What is your presentation about?
My presentation discusses an important and unresolved question in the field of adipose tissue developmental biology: “How are adipocyte precursor cells regulated in vivo to control adipose tissue expansion in obesity, and in a fat depot-specific manner?” The mechanisms controlling differential adipocyte stem cell activity across anatomically distinct depots have been almost entirely unclear. Understanding these mechanisms is critical as it speaks to the manner in which regional body fat distribution is controlled in obesity, and how individual fat depots expand and remodel in the setting of caloric excess.

What makes this topic important in 2021?
Body fat distribution is an important determinant of insulin sensitivity in obesity. Understanding how to control healthy adipose tissue expansion in the face of caloric excess may help devise strategies to uncouple obesity from diabetes.

Which subset of attendees shouldn’t miss this presentation?
Basic scientists and clinical researchers with an interest in adipocyte development and the regulation of body fat distribution in obesity will be interested in this presentation.

What else should Scientific Sessions attendees know about your presentation?
The presentation will describe current knowledge of the heterogeneity of adipocyte progenitor cells based on cutting-edge techniques in single-cell transcriptomics and genetic mouse models.


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