2025 PRESENTER PROFILES
New Molecular Regulators of Energy Metabolism Independent of Appetite Suppression
Sunday, June 22, at 8:00 a.m. CT
Room W194 AB • McCormick Place Convention Center
Adipsin and Complement in Peripheral Metabolism
James C. Lo, MD, PhD
Associate Professor,
Weill Cornell Medicine
What is your presentation about?
My presentation will cover how the adipokine adipsin/complement factor D can regulate functions in different tissues. This is partly done through the complement receptor C3aR1 that is broadly expressed. We find that C3aR1 signaling has notable and sometimes opposing functions in adipocytes and beta-cells.
How do you hope your presentation will impact diabetes research or care?
This work informs on how molecular signals can have different impacts on each tissue. This is important because diabetes and its treatments affect the whole body.
How did you become involved with this area of diabetes research or care?
I was always intrigued by how the immune system can impact metabolism and vice versa. This line of work is a nice case study of how adipocytes secrete an immune/complement factor that orchestrates metabolic homeostasis.