Subrata Chakrabarti, MBBS, PhD, FRCP(C)
Distinguished University Professor,
Western University
Featured in the Session: Molecular Architecture of Diabetic Retinopathy: Genes and Epigenomics
When
Monday, June 8
at 8:00 a.m. CT
Where
R05 (Level 2)
Ernest N. Morial Convention Center
What is your presentation about?
This presentation will examine roles of various long non-coding RNAs in the development of diabetes-related retinopathy, a leading cause of global blindness. Long-non-coding RNAs are important regulators in almost all cellular processes. Detailed analyses of long non-coding RNAs in the retina in diabetes have led to the development of a potential treatment target, HOTAIR. The presentation will also focus on preclinical studies leading to the development of a potential siRNA treatment for diabetes-related retinopathy using an eyedrop.
How do you hope your presentation will impact diabetes research or care?
This novel, non-invasive RNA therapeutic for diabetes-related retinopathy is robust and may potentially be transformative. If successful, this approach may significantly alleviate sufferings of patients with diabetes and reduce the burden of blindness globally.
How did you become involved with this area of diabetes research or care?
I am involved in the research of diabetes-related retinopathy and other chronic diabetes-related complications for a significant period of time. My research goal always focused on better understanding of pathogenetic mechanisms, so that specific treatment could be developed. Such approaches have led to exploration of epigenetic mechanisms and current research.