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Presenter Profile: Channeling Mechanisms Underlying Islet Function and Dysfunction

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2024 Presenter Profiles

Channeling Mechanisms Underlying Islet Function and Dysfunction

Saturday, June 22, at 1:30 p.m. ET
Room W415B (Valencia Ballroom)
Orange County Convention Center

{Livestream Available)


Impact of Intracellular Calcium Flux on Beta-Cell Insulin Secretion

Marjan Slak Rupnik, PhD
Marjan Slak Rupnik, PhD

Marjan Slak Rupnik, PhD

Principal Investigator,
Medical University of Vienna

What is your presentation about?
Transient phenomena in intracellular calcium ion fluxes in Beta-cells that regulate insulin granule exocytosis and cell collective activity. The focus will be on the intricate interplay between IP3 and ryanodine receptor activity, the multidimensionality of Beta-cell activation/inhibition, and how data science approaches can promote high-throughput analysis of Beta-cell collectives.

How do you hope your presentation will impact diabetes research or care?
New insights into the delicate mechanisms that regulate intracellular calcium ion release and Beta-cell collective activity are critical for understanding Beta-cell physiology and pathophysiology, as well as for unraveling the conditions for studying new pharmacological targets and translating them into diabetes care.

How did you become involved with this area of diabetes research or care?
I am a neuroscientist trained in patch-clamp technique, endocrine tissue slicing, and high-end light microscopy to follow ion channels, granule exocytosis, and intracellular calcium ion homeostasis. I entered the field more than 20 years ago by extending our expertise to the preparation of pancreatic tissue slices in rodents. More recently, we have developed a number of high-throughput analytical approaches to study Beta-cell function and the role of intracellular calcium ion release channels in this function.

Register Today for the 84th Scientific Sessions


Join us in Orlando for the 84th Scientific Sessions, June 21-24. Full in-person registration includes access to all of the valuable onsite content during the meeting and on-demand access to the virtual program June 25-Aug. 26. For those unable to join us in-person, we are planning a virtual program to allow as many people as possible to participate and learn about the latest advances in diabetes research, prevention, and care.