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Presenter Profile: A Means to an Endpoint—Establishing Meaningful Outcomes in Clinical Neuropathy Trials


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2024 Presenter Profiles

A Means to an Endpoint—Establishing Meaningful Outcomes in Clinical Neuropathy Trials

Monday, June 24, at 8:00 a.m. ET
Room W206
Orange County Convention Center

Meaningful Endpoints in Clinical Trials—Lessons Learned

Rodica Busui, MD, PhD
Rodica Busui, MD, PhD

Rodica Busui, MD, PhD

Larry D. Soderquist Professor of Diabetes, Metabolism, Endocrinology, Internal Medicine,
University of Michigan

What is your presentation about?
I will discuss lessons learned on the design and main outcomes selection for diabetic neuropathy and their impact on the landscape for developing effective disease-modifying and neuropathic pain therapies for people with diabetes who are affected by these very prevalent and challenging complications, including data from recent trials.

How do you hope your presentation will impact diabetes research or care?
Diabetic neuropathy and associated neuropathic pain are one of the most prevalent and invalidating diabetes complications for both people with type 1 and type 2 diabetes, with direct impact on loss of sensation, with subsequent increase risk for falls, fractures, loss of daily function, severe pain that is very challenging to treat, leading to anxiety, depression, sleep deprivation, polypharmacy and associated side effects, including dependence. It is also the leading cause of foot ulcers and amputations, and an independent predictor of mortality in people with diabetes. Unfortunately, to date, these remain orphan complications, given the lack of disease-modifying therapies and mostly ineffective pain reduction agents. Thus, using the knowledge learned from these lessons is critical to advance the field, engage pharma, and develop safe and effective therapeutic strategies

How did you become involved with this area of diabetes research or care?
See above. I have dedicated my career to fighting all complications of diabetes, and helping people with diabetes live a better life.

Register Today for the 84th Scientific Sessions

Join us in Orlando for the 84th Scientific Sessions, June 21-24. Full in-person registration includes access to all of the valuable onsite content during the meeting and on-demand access to the virtual program June 25-Aug. 26. For those unable to join us in-person, we are planning a virtual program to allow as many people as possible to participate and learn about the latest advances in diabetes research, prevention, and care.