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RISE Study continues to provide insight into progression of type 2 diabetes in youth


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2 minutes

Steven E. Kahn, MB, ChB
Steven E. Kahn, MB, ChB

Ongoing data analyses from the RISE Study continue to shed light on important differences between adults and youth in the onset and progression of type 2 diabetes.

A panel of RISE investigators will discuss the latest findings during the Virtual 80th Scientific Sessions symposium New Insights from the Restoring Insulin Secretion (RISE) Study—Differences Between Adults and Youth with Prediabetes and Type 2 Diabetes, which will begin at 12:00 p.m. CT on Sunday, June 14.

“The RISE Study has previously reported that prediabetes and type 2 diabetes in youth is characterized by an inability of insulin to act normally in the tissues, and an inability of the islet beta cell to secrete sufficient insulin to maintain normal glucose levels,” said RISE Steering Committee Chair Steven E. Kahn, MB, ChB, Professor of Medicine and the Leonard L. Wright & Marjorie C. Wright Term Chair at the University of Washington and VA Puget Sound Health Care System.

“These abnormalities are similar to those in adults with these disorders,” Dr. Kahn continued. “However, despite interventions that would be anticipated to reduce or even reverse these defects as observed in adults, they have no effect in youth. Thus, the beta-cell defect becomes even more severe during 12 months of active treatment.”

The symposium’s panelists will examine possible reasons for the more rapid progression of type 2 diabetes in youth and suggest areas for continued research. The researchers will highlight three key areas where the RISE Study is providing valuable insight:

  • The beta-cell defect in youth is one of abnormal sensing of glucose, a defect that is present early and is progressive over time
  • Increased alpha-cell function does not explain the observation of increased insulin secretion in youth versus adults
  • Metabolic factors predict the worsening of glucose control in youth and adults, with the loss of beta-cell function shown to be most critical to disease progression

“Additional work is required to better understand the mechanisms responsible for the aggressive disease in youth. Understanding these should provide insight into the development of new approaches to prevent and treat type 2 diabetes in youth,” Dr. Kahn said. “Studies in youth need to be expanded to include testing of new approaches to therapy, including medications and bariatric surgery as applied in adults.”


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