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Presenter Profiles: SARS-CoV-2 Infection Induces Beta-Cell Transdifferentiation


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SARS-CoV-2 Infection Induces Beta-Cell Transdifferentiation

Friday, June 3 at 11:30 a.m. CT
La Nouvelle Orleans Ballroom C
Level 2, Ernest N. Morial Convention Center


Streaming: Live and On-Demand

Q&A with Shuibing Chen, PhD

Weill Cornell Medicine

Shuibing Chen, PhD
Shuibing Chen, PhD

What is your presentation about?

  • SARS-CoV-2 viral antigen is detected in beta cells of autopsies of COVID-19 subjects.
  • SARS-CoV-2-induced beta cell transdifferentiation is mediated by eIF2 pathway.
  • Trans-ISRIB reverses SARS-CoV-2 infection-induced beta cell transdifferentiation.
  • Proinflammatory macrophages are activated in SARS-CoV-2 infected human islets, as well as autopsies of COVID-19 subjects.

What makes this topic important in 2022?
COVID-19 is affecting everyone’s daily life throughout the world, and recent epidemiology studies suggest an increased risk of diabetes in young adults diagnosed with COVID-19.

How did you become involved with this area of diabetes research or care?
I was inspired by my postdoctoral mentor, Dr. Douglas Melton. When I joined Melton lab back in 2007, Doug focused on developing strategies to convert stem cells to pancreatic beta cells for replacement therapy for diabetic patients. After I became independent, I continued working in this field and used stem cell models to study the impact of genetic and environmental factors on diabetes progression.