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Presenter Profile: Insights into Novel Determinants of Outcomes in Pregnancies Complicated by Hyperglycemia


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Insights into Novel Determinants of Outcomes in Pregnancies Complicated by Hyperglycemia

Friday, June 23, at 2:00 p.m. PT
Room 31
San Diego Convention Center

Presentation: Newborn Adiposity and Cord Blood DNA Methylation—An Epigenome-Wide Association Study in HAPO with Validation in Gen3G

Jami L. Josefson MD, MS

Associate Professor,
Northwestern University Feinberg School of Medicine / Lurie Children’s Hospital of Chicago

What is your presentation about?
This oral abstract will report findings from the multiethnic, multinational prospective birth cohort, the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study in which we conducted an epigenome-wide association study on stored cord blood. We assessed the association between newborn adiposity in nearly 3000 infants with cord blood DNA methylation and identified 90 significant CpG sites after accounting for multiple testing and maternal covariates. We then replicated the findings in a separate cohort and identified seven CpG sites in genes which regulate cell growth.

What makes this topic important in 2023?
The findings support epigenetic mechanisms in the developmental origins of newborn adiposity.

How did you become involved with this area of diabetes research or care?
I am interested in optimizing pregnancy metabolic health to promote healthy metabolism in children and avoid obesity and metabolic diseases.

How do you think your presentation will impact diabetes research or care?
Identifying children at risk of metabolic disease will enable targeted prevention against obesity and type 2 diabetes.

What are you most looking forward to at the 83rd Scientific Sessions?
Interacting in person with scientists and diabetes providers from across the world and discussing new research findings.