The COORDINATE-Diabetes trial studied the impact of a multifaceted educational intervention for clinical staff on prescription rates for three groups of therapies used to treat type 2 diabetes and cardiovascular disease. “COORDINATE shows that it is possible to change prescribing behavior using a process that is not resource intensive,” said Principal Investigator Christopher B. Granger, MD, FACC, FAHA. Read more

Researchers presented results from their studies of the effects of retatrutide on obesity, type 2 diabetes, and nonalcoholic steatohepatitis. “The most interesting reason to pursue glucagon agonism in a multi-receptor agonist is the possibility that you could alter hepatic liver metabolism and potentially decrease fatty acid accumulation and hypertriglyceridemia,” said David A. D’Alessio, MD. Read more

A panel of investigators shared conclusions from two clinical trials studying the efficacy of oral semaglutide in treating diabetes and obesity. “The availability of an oral GLP-1 with weight-lowering efficacy could potentially give people requiring treatment for obesity and their physicians a great option for choice of treatment,” said Julio Rosenstock, MD. Read more

ARMMS-T2D showed gastric bypass, sleeve gastrectomy, and adjustable gastric band surgeries to be more effective than intensive medical and lifestyle management for individuals with type 2 diabetes. Anita Courcoulas, MD, MPH, shared results from the prospective, observational follow-up to four trials comparing surgery and medical management. Read more

Experts including cardiologist Heather M. Johnson, MD, MS, MMM, analyzed the association of hyperlipidemia, hypertension, and glucose levels with macrovascular risk at the 83rd Scientific Sessions. Their discussion focused on a case study of a patient with diabetes and hypertension to determine the best treatment to manage both. Read more