This symposium will include presentations on the pathophysiology-based subgrouping in diabetes and prediabetes, the heterogeneity in the pathogenesis and underlying mechanisms of type 2 diabetes, and differential intervention and treatment effects in type 2 diabetes trials. The session will begin at 2:00 p.m. CT on Friday in La Nouvelle Orleans Ballroom C at the convention center. A livestream and on-demand recording are available at ADA2022.org