Ethnic Differences in Pancreatic Hormone Secretion in Health and T2D
Board No. 253
Poster Hall (Halls D-E)
Level 1, Ernest N. Morial Convention Center
Q&A with Nicolai Doliba, PhD, DSc
University of Pennsylvania
What is your presentation about?
I will present new evidence of alpha cell dysfunction during the development of diabetes, which is apparent even in early stages with the presence of single autoantibody positivity but normal blood glucose. I will also discuss differences in hormone secretion and calcium signaling between different ethnic groups in both health and in diabetes. These new findings in alpha cells may help to develop a targeted intervention to delay diabetes in high-risk populations.
What makes this topic important in 2022?
Until recently, glucagon-secreting alpha cells have been under-appreciated in the characterization of diabetes. Diabetes should be considered a bihormonal disease.
How did you become involved with this area of diabetes research or care?
I am involved in the physiological phenotyping of isolated islets from healthy and diabetic donors through the Human Pancreas Analysis Program (HPAP).
What are you most looking forward to at the 82nd Scientific Sessions?
I am looking forward to seeing the latest discoveries in pancreatic islet research.