Effects of Exosomal miRNAs in Gestational Diabetes on Muscle Insulin Sensitivity
Level 1, Ernest N. Morial Convention Center
Q&A with Carlos Salomon, BSc (Hons I), MPhil, DMedSc, PhD
Associate Professor, Head of the Exosome Biology Laboratory,
The University of Queensland
What is your presentation about?
Gestational Diabetes Mellitus (GDM) is a serious public health issue affecting 9-15% of all pregnancies worldwide. Unfortunately, the molecular mechanisms underlying GDM are poorly understood, representing a major roadblock to the development of efficacious specific prevention strategies and treatments. We proposed that nucleotide sorting motifs regulate the packaging of specific miRNA into placental small extracellular vesicles (sEV). When released into the material circulation these sEV control insulin sensitivity during gestational diabetes mellitus (GDM).
What makes this topic important in 2022?
When verified, this novel concept will represent a paradigm shift in our understanding of how maternal metabolic adaptations are regulated during pregnancy. Specifically, that extracellular vesicle signaling by the placenta regulates pregnancy-induced maternal insulin resistance.
How did you become involved with this area of diabetes research or care?
I have been working in diabetes research for the last 14 years, focusing on the role of placental factors inducing insulin resistance in Gestational Diabetes Mellitus (GDM). Unfortunately, GDM is associated with fetal overgrowth, increased perinatal morbidity and mortality, and susceptibility to develop type 2 diabetes and cardiovascular disease later in life in both the mother and infant.
What are you most looking forward to at the 82nd Scientific Sessions?
I am very excited about the ADA meeting this year because it is my first international meeting in 2 years due to the COVID-19 pandemic. I am looking to get feedback on our research findings, hear about the latest diabetes research, and get to know other people in the diabetes field.