The Regulation of Health Span and Longevity by Specific Dietary Macronutrients
Sunday, June 27, at 4:54 p.m. ET
Q&A with Dudley Lamming, PhD
What is your presentation about?
Protein-restricted diets promote health and longevity. I will discuss our findings that the metabolic effects of protein restriction can be attributed to reduced dietary levels of the branched-chain amino acids (BCAAs) leucine, isoleucine, and valine. We find that restricting dietary BCAAs leads to a 30% increase in life span and a reduction in frailty in male, but not female, wild-type mice when they undergo lifelong feeding. Our results demonstrate that restricting dietary BCAAs can increase health span and longevity in mice and suggest that reducing dietary BCAAs may hold potential as a translatable intervention to promote healthy aging.
What makes this topic important in 2021?
Age-related diseases, including diabetes and obesity, are the major causes of morbidity and mortality in the United States and are a growing problem worldwide as global life expectancy increases.
Which subset of attendees shouldn’t miss this presentation?
A must-see for those interested in how nutrition can affect healthy aging.
What else should Scientific Sessions attendees know about your presentation?
Much of the work discussed here can be found online at https://www.nature.com/articles/s43587-020-00006-2/ and https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00166-2